Physician Assistant Jobs in San Diego, CA

San Diego, California$164,250 USD/yearFull-timeTech Hub
Updated: June 2026Expert reviewed|Data sourced from BLS, Glassdoor, and industry reports

About Physician Assistant Jobs in San Diego

Looking for a Physician Assistant job in San Diego? You're in the right place. This guide covers everything you need to know about working as a Physician Assistant in San Diego, CA.

We'll show you what you can expect to earn. We'll also share which companies are hiring. Plus, you'll learn about the cost of living and how to get started in your job search.

San Diego has a strong job market for Physician Assistants. Many employers are actively looking for talent. Read on to learn how to land your next role.

Physician Assistant Salary in San Diego

Entry Level
$117,895
Median
$164,250
Senior Level
$218,270

Physician Assistant salaries in San Diego are 46% above the national average, reflecting the high cost of living.

Purchasing power in San Diego is comparable to the national average, with salaries appropriately scaled to local costs.

Required Skills

Clinical AssessmentDiagnosisTreatmentProceduresPatient Care

Physician Assistant Job Market in San Diego

San Diego, CA is a major regional employment hub for Physician Assistant professionals. With a population of 1.4 million, the San Diego-Chula Vista-Carlsbad metro area offers diverse opportunities across multiple industries. The city's strong Biotechnology and Defense sectors create robust demand for Physician Assistant talent. The market for Physician Assistant positions remains stable, with opportunities in both established companies and growing organizations.

What it's like to job-hunt for Physician Assistant roles in San Diego

San Diego's Biotechnology sector is one of the leading employers of Physician Assistants in California. With approximately 1,423,851 residents in the metro area, the Physician Assistant job market here is shaped by long-established firms in Biotechnology and Defense alongside a growing roster of newer entrants.

Median compensation for Physician Assistant roles in San Diego sits near $164,250 annually. The cost-of-living index here is 146 — above the US average of 100, but not dramatically so. Real take-home for the role is in line with what a candidate of similar experience would earn in most major US metros, with the usual variation by employer size and benefits package.

Physician Assistant demand in San Diego has been relatively stable over the past 2-3 years. Net hiring is largely backfill-driven rather than expansion, which means each opening is more competitive but also more durable. Senior candidates with established local networks have the strongest advantage.

Hybrid arrangements have become the norm for Physician Assistant roles in San Diego, with most employers expecting 2-4 days per week in the office. Fully remote variants exist but are usually reserved for senior or specialized hires. Junior candidates should expect to be on-site most of the week.

Core skills that consistently show up in San Diego Physician Assistant postings include Clinical Assessment, Diagnosis, Treatment, and Procedures. Candidates whose resumes lead with measurable outcomes against these specific skills (project counts, quantified impact, recognized certifications) tend to move through screening faster than those leading with general experience claims.

San Diego's Physician Assistant hiring market rewards targeted, well-researched applications more than mass outreach. Identify 15-20 employers actively hiring, tailor your resume to each posting's exact language, and pair that with a direct LinkedIn connection request to the hiring manager when possible.

Top Companies Hiring Physician Assistants in San Diego

Scripps HealthSharp HealthCareUC San Diego HealthKaiser Permanente

Major employers hiring Physician Assistants in San Diego include Scripps Health, Sharp HealthCare, UC San Diego Health, Kaiser Permanente. With major hospital systems and research institutions, San Diego offers excellent opportunities for healthcare professionals at all career stages. Many companies offer competitive benefits including comprehensive healthcare, and professional development opportunities.

Cost of Living for Physician Assistants in San Diego

Living in San Diego as a Physician Assistant means navigating a cost of living that's significantly above the national average (146% of baseline). Average rent for a 1-bedroom apartment is approximately $2,400/month (33% above the national average of $1,800). At median Physician Assistant salary, housing is quite affordable at 18% of gross income, leaving room for savings and lifestyle spending. Suburban apartments average $1,900/month, offering significant savings with slightly longer commutes.

146
Cost Index (100=avg)
$2.4K
Avg Rent/Month
Yes
Tech Hub
Tier 2
Market Size

Commuting as a Physician Assistant in San Diego

San Diego Limited public transit options; car recommended for most commutes. The average commute time is 25 minutes. Research employer-specific shuttle services. Consider living close to your workplace. Since transit options are limited, consider living close to your workplace or negotiating flexible hours to avoid peak traffic.

Best neighborhoods for Physician Assistants in San Diego: Downtown (Central business district with tech companies); Tech Park/Campus (Suburban office park developments). Downtown is particularly popular among Physician Assistant professionals due to proximity to major employers and urban amenities.

Tax Considerations in California

California has relatively high state income taxes. A Physician Assistant earning $164,250 might pay approximately $13,140 in state income tax. However, California's strong job market and quality of life often offset the higher tax burden.

Career Outlook for Physician Assistants

The job outlook for Physician Assistants in San Diego is stable. While not experiencing rapid growth, the field maintains steady demand with consistent opportunities for qualified professionals. San Diego's growing economy creates new positions regularly, often with less competition than coastal tech hubs. In-demand skills include Clinical Assessment, Diagnosis, Treatment, Procedures.

Relocating to San Diego

California has higher state income taxes. Factor this into salary negotiations, as gross salary comparisons can be misleading.

Frequently Asked Questions

What is the average Physician Assistant salary in San Diego, CA?

The average Physician Assistant salary in San Diego, CA is $164,250 per year. Entry-level Physician Assistants typically start around $117,895, while experienced professionals can earn $218,270 or more. The national average for Physician Assistant roles is $112,500.

How many Physician Assistant jobs are available in San Diego?

San Diego has a strong job market with regular openings for Physician Assistant professionals. Major employers hiring Physician Assistants include Scripps Health, Sharp HealthCare, UC San Diego Health, Kaiser Permanente. The Biotechnology and Defense sectors drive much of the demand in this market.

Is San Diego a good city for Physician Assistants?

San Diego is an excellent choice for Physician Assistants. As a major metro area, it offers abundant opportunities and competitive salaries. However, be aware of the higher cost of living when evaluating offers. The city's biotechnology industry creates strong demand for healthcare professionals.

What skills are most in-demand for Physician Assistants in San Diego?

Top skills for Physician Assistants in San Diego include Clinical Assessment, Diagnosis, Treatment, Procedures, Patient Care. Employers value both technical expertise and soft skills like communication and teamwork.

What is the cost of living for Physician Assistants in San Diego?

San Diego's cost of living is significantly above the national average (146% of baseline). Average rent for a 1-bedroom apartment is approximately $2,400/month. Purchasing power in San Diego is comparable to the national average, with salaries appropriately scaled to local costs.

How is the commute for Physician Assistants in San Diego?

San Diego Limited public transit options; car recommended for most commutes. The average commute is 25 minutes. Research employer-specific shuttle services.

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